Dermatix. Improves Scars. Rebuilds Confidence.

Mechanism of Action

"The mechanism of action of silicone therapy has not been completely determined but is likely to involve occlusion and hydration of the stratum corneum with subsequent cytokine-mediated signaling from keratinocytes to dermal fibroblasts."
Mustoe TA. Aesthetic Plastic Surgery 2008; 32: 82-92
Injury increases Transepidermal Water Loss (TEWL)
Illustration of Injury increases Transepidermal Water Loss (TEWL)
Osmotic gradient signals dehydration of stratum corneum to keratinocytes
Illustration of Osmotic gradient signals dehydration of stratum corneum to keratinocytes
 
  • Keratinocytes produce cytokines
  • Activation of dermal fibroblasts to synthesise and release collagen
  • Excessive collagen formation
  • Abnormal scarring
Dermatix® restores barrier function, reduces TEWL and consequently reduces activation of fibroblasts
Illustration of Silicone gel restores barrier function, reduces TEWL and consequently reduces activation of fibroblasts
 
  • Dermatix® restores barrier function
  • TEWL reduced + stimulation of keratinocytes is stopped
  • Activation of dermal fibroblasts stopped
  • After 2-3 months of Dermatix® treatment collagen deposition is normalized
RECUCED SCAR HYPERTROPHY
Eng | 繁