Dermatix. Improves Scars. Rebuilds Confidence.

Proven Efficacy

"Silicone gel dispensed from a tube has significant benefits in ease of use, but different formulations of silicone gel may vary in efficacy."[1]
Studies on the Efficacy of Dermatix® in Scar Management

Study Patients Intervention Scar evaluation Outcome
Controlled comparative studies
Chan et al. [2];
prospective, randomized, double-masked, within-subject comparison study		 50 Asian patients who underwent median sternotomy Twice-daily silicone gel on half of wound compared with placebo gel on other half of wound from postoperative week 2 to month 3 Vancouver Scar Scale scores of pigmentation, vascularity, pliability, height, pain, and itchiness Scars that developed during silicone gel treatment were significantly flatter, less red, and more pliable and associated with significantly less pain and itching than scars that developed during placebo treatment
Signorini and Clementonil[3];
prospective, randomized, parallel-group comparison study		 160 patients who underwent surgery Twice-daily silicone gel treatment compared with no treatment initiated from 10 days to 3 weeks after surgery for 4 months Scar quality (normal mature, slightly hypertrophic,hypertrophic, or keloid scar based on color, hardness, elevation, and relationship to wound margins) Scar quality was significantly better in the silicone gel group than in the no treatment group at the 6-month follow-up visit: the incidence of hypertrophic or keloid scarring was 7% in the silicone gel group compared with 26% in the no treatment group
Chernoff et al. [4];
prospective, within-subject comparison study		 30 patients with bilateral hypertrophic scars, keloids, or scars still in an erythematous and raised stage of healing Silicone gel, SGS, or a combination of treatments for one scar compared with no treatment for the bilateral scar for 3 months Scar elevation and skin surface texture measured using optical profilometry; erythema; pliability; severity of symptoms Scars treated with silicone gel, SGS, or silicone gel/SGS were statistically significantly less elevated. less red, and associated with fewer symptoms than untreated scars
Fonseca Capdevila et al. [5];
prospective, parallel-group comparison study		 132 patients who underwent removal of a benign skin lesion Silicone gel treatment compared with SGS treatment initiated within 1 month of surgery Height; redness; pliability; itching; pain/tenderness Silicone gel and SGS were both effective in improving scar redness, hardness, elevation, pain, and itching; there were no statistically significant differences between silicone and SGS on any efficacy parameter at the month 6 follow-up
Large-scale observational study
Sepehrmanesh [6];
prospective, open-label, non-controlled study		 1,522 patients with scars Silicone gel was applied on average twice daily for 2 to 6 months, maximum 10 months Height; color; pliability; itching; pain/tenderness Improvement in scar color, pliability, height, itching, and pain/tenderness after silicone gel treatment of approximately 70% to 84.2% of patients
Small case series
Murison and James [7];
prospective, noncontrolled study		 6 patients with excessive scars (most at least 2 years old) Silicone gel used for 8 weeks Adapted Vancouver Scar Scale scores of elevation, redness, hardness, itching, tenderness and pain; collagen content and blood flow measured using intracutaneous spectrophotometry All scars showed improvement in redness, elevation, hardness, and itching, and pain was reduced in symptomatic scars
References:
  1. Mustoe TA. 21st World Congress of Dermatology, 2007
  2. Chan KY, Lau CL, Adeeb SM, Somasundaram S, Nasir-Zahari M (2005) A randomized, placebo-controlled, double-blind, prospective clinical trial of silicone gel in prevention of hypertrophic scar development in median sternotomy wound. Plast Reconstr Surg 116:1013-1020
  3. Signorini M, Clementonil MT (2007) Clinical evaluation of a new self-drying silicone gel in the treatment of scars: A preliminary report. Aesth Plast Surg 31:183-187
  4. Chernoff WG, Cramer H, Su-Huang S The efficacy of topical silicone gel elastomers in the treatment of hypertrophic scars, keloid scars, and postlaser exfoliation erythema. Aesth Plast Surg, doi:10.1007/s00266-006-0218-1
  5. Mustoe TA. Aesth Plast Surgery 2008; 32(1): 82-92
  6. Sepehrmanesh M (2006) Observational study of 1,522 patients using Dermatix gel. Kompendium Dermatologie 1:30–32
  7. Murison M. James WJ Plast Reconstr Aesth Surg 2006. 59: 437-439
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